Veterinary Peptide & Repurposed Drug Protocol Guide
A comprehensive, evidence-based resource for pet owners and veterinarians exploring peptide and repurposed drug research for animal health. Every protocol sourced from peer-reviewed studies, graded for evidence quality.
Research & Legal Disclaimer: This is an independent, non-commercial educational resource. No products are sold, endorsed, or promoted. Content is derived from published peer-reviewed literature for educational purposes only. This does not constitute veterinary medical advice. Most compounds listed are investigational or used off-label and are not FDA-approved for veterinary oncology. Extralabel drug use in animals requires a valid VCPR and veterinary supervision under AMDUCA.
How to Use This Guide
Compounds, protocols, and combinations organized by species and clinical goal, each graded for the strength of supporting evidence.
Species Protocols
Dosing, frequency, and cycling tailored to canine, feline, and equine patients.
Combinations
Multi-compound stacks targeting complementary biological pathways.
Injection Sites
Visual guidance for subcutaneous, intramuscular, topical, and intratumoral routes.
Reconstitution
Step-by-step mixing, concentration math, and storage stability.
Glossary
Plain-language definitions of the key terms used throughout the guide.
References
Every protocol traced back to its peer-reviewed source literature.
Reading the Evidence Grades
Each compound is graded so you can weigh research support before considering any protocol.
Good Evidence
Multiple studies in target species or approved in 2+ countries. Published clinical data with known safety profile. Does not mean "proven." Means evidence base is meaningfully established.
Emerging Evidence
Some published data supports this use, but limited to one species, one study, preclinical models, or extrapolated using allometric scaling. Promising but incomplete.
Preliminary / In Vitro Only
Evidence limited to cell culture, rodent models, or mechanistic reasoning. No companion animal data exists. Highly experimental, included for completeness, not endorsement.
Glossary of Key Terms
The vocabulary you'll encounter across the protocols.
VCPR
Veterinarian-Client-Patient Relationship — legal requirement for a vet to know your animal before prescribing treatment.
AMDUCA
Animal Medicinal Drug Use Clarification Act — federal law allowing vets to use approved drugs off-label under a valid VCPR.
BSA Scaling
Body Surface Area scaling — standard method for converting drug doses between species based on metabolic rate, not just body weight.
Km Factor
Species-specific conversion constant. Dog = 20, Cat = 12, Horse = 36.2. Higher Km = slower relative metabolism per kg.
SQ / SubQ
Subcutaneous — injection under the skin into the fat layer. Most common route for peptide administration in pets.
IM
Intramuscular — injection directly into muscle tissue. Used for some peptides, particularly TB-500 in horses.
Reconstitution
Mixing freeze-dried (lyophilized) peptide powder with sterile bacteriostatic water to create injectable solution.
FISS
Feline Injection-Site Sarcoma — tumors caused by repeated injection site inflammation. Avoid interscapular injections in cats.
MDR1
Multi-Drug Resistance 1 gene — mutation in herding breeds causing inability to metabolize certain drugs, including ivermectin.